Tone-Kari K. Østbye

I work with muscle quality and nutrition in Atlantic salmon focusing on muscle deformity, muscle structural and muscle regulatory factors, oxidative stress, apoptosis, and fatty acid metabolism. I make use of techniques like cell culturing, quantitative PCR, microarray, cloning, immunocytochemistry, and Western blotting. I received a master degree in biotechnology from the University in Tromsø and the master thesis in medical genetics from the University Hospital North Norway. My doctoral degree within molecular fish biology and muscle regulatory factors in Atlantic salmon is from Nofima Marin (formerly Institute of Aquaculture Research) and the Norwegian University of Life Sciences.

+47 64 97 03 84

tone-kari.ostbye@nofima.no

Ås

Nutrition and feed technology

See publications in Cristin

My Projects

CrispResist

Harnessing cross-species variation in sea lice resistance

2021 - 2024

Genomics4Robust

Integrating genomics resources for robust fish for the future

2021 - 2023

The active substances in herring roe that produce healing effects in mild to moderate psoriasis

2021 - 2023

CMSEdit

Gene editing for CMS resistance in salmon

2019 - 2023

BALANCE

Metabolic imbalance in Atlantic salmon – Significance of the interaction between nutrition and genetics

2017 - 2020

FeedMod

Better methods to understand fish digestion

2017 - 2019

Pigmentation in salmon

How feed controls pigmentation in salmon

My publications

Tone-Kari K. Østbye has 75 publications at Nofima:

Oxidized Dietary Oil, High in Omega-3 and Omega-6 Polyunsaturated Fatty Acids, Induces Antioxidant Responses in a Human Intestinal HT29 Cell Line

Nutrients, 2022
Academic article

EX-spot: Mørke flekker i laksefilet. Årsak til dannelse og tiltak som hemmer utvikling

2022
Nofima’s reports

A dose-response study with omega-3 rich canola oil as a novel source of docosahexaenoic acid (DHA) in feed for Atlantic salmon (Salmo salar) in seawater; effects on performance, tissue fatty acid composition, and fillet quality

Aquaculture, 2022
Academic article

Applying genetic technologies to combat infectious diseases in aquaculture

Reviews in Aquaculture, 2022
Academic literature review

Differential Expression of miRNAs and Their Predicted Target Genes Indicates That Gene Expression in Atlantic Salmon Gill Is Post-Transcriptionally Regulated by miRNAs in the Parr-Smolt Transformation and Adaptation to Sea Water

International Journal of Molecular Sciences, 2022
Academic article

Expression Analysis in Atlantic Salmon Liver Reveals miRNAs Associated with Smoltification and Seawater Adaptation

Biology (Basel), 2022
Academic article

Increasing dietary levels of the n-3 long-chain PUFA, EPA and DHA, improves the growth, welfare, robustness and fillet quality of Atlantic salmon in sea cages

British Journal of Nutrition, 2022
Academic article

Environment and feeding for optimal health and survival of cleaner fish in sea cages

2022
Nofima’s reports

Trenger laks fettsyren EPA for optimal immunrespons? Rapport FHF prosjekt EPA-laks

2021
Report

Transcriptome and functional responses to absence of astaxanthin in Atlantic salmon fed low marine diets

Comparative Biochemistry and Physiology - Part D:Genomics and Proteomics, 2021
Academic article

Optimising dietary fatty acids and lipids of Atlantic salmon to secure their health and welfare through varying environmental conditions and life stages [OptiHealth]

2021
Nofima’s reports

A de novo Full-Length mRNA Transcriptome Generated From Hybrid-Corrected PacBio Long-Reads Improves the Transcript Annotation and Identifies Thousands of Novel Splice Variants in Atlantic Salmon

Frontiers in Genetics, 2021
Academic article

Rest Plant Materials with Natural Antioxidants Increase the Oxidative Stability of Omega-3-Rich Norwegian Cold Pressed Camelina sativa Oil

ASC Food & Science Technology, 2021
Academic article

Deposition and metabolism of dietary n-3 very-long-chain PUFA in different organs of rat, mouse and Atlantic salmon

British Journal of Nutrition, 2021
Academic article

Modulation of hepatic miRNA expression in Atlantic salmon (Salmo salar) by family background and dietary fatty acid composition

Journal of Fish Biology, 2021
Academic article

Sensitivity to Dietary Wheat Gluten in Atlantic Salmon Indicated by Gene Expression Changes in Liver and Intestine

Genes, 2020
Academic article

Characterization of Differentially Expressed miRNAs and Their Predicted Target Transcripts during Smoltification and Adaptation to Seawater in Head Kidney of Atlantic Salmon

Genes, 2020
Academic article

Sudden increased mortality in large seemingly healthy farmed Atlantic salmon (Salmo salar L.) was associated with environmental and dietary changes

Journal of Applied Aquaculture, 2020
Academic article

DHA modulates immune response and mitochondrial function of atlantic salmon adipocytes after LPS treatment

International Journal of Molecular Sciences, 2020
Academic article

Biotransformation of phytoestrogens from soy in enzymatically characterized liver microsomes and primary hepatocytes of Atlantic salmon

Ecotoxicology and Environmental Safety, 2020
Academic article

North Atlantic fish oils and importance for utilization of omega-3 fatty acids

2020
Nofima’s reports

Lipid deposition and mobilisation in atlantic salmon adipocytes

International Journal of Molecular Sciences, 2020
Academic article

Effekt av fôr, temperatur og stress på pigmentering i laks-Faglig sluttrapport

2019
Report

Application of Molecular Methods in Aquaculture and Fishery

2019
Academic chapter/article/Conference paper

Dietary Fish Oil Alters DNA Methylation of Genes Involved in Polyunsaturated Fatty Acid Biosynthesis in Muscle and Liver of Atlantic Salmon (Salmo salar)

Lipids, 2019
Academic article

The long-chain monounsaturated cetoleic acid improves the efficiency of the n-3 fatty acid metabolic pathway in Atlantic salmon and human HepG2 cells

British Journal of Nutrition, 2019
Academic article

The possible involvement of oxidative stress in the oocyte ageing process in goldfish Carassius auratus (Linnaeus, 1758)

Scientific Reports, 2019
Academic article

n-3 canola oil effectively replaces fish oil as a new safe dietary source of DHA in feed for juvenile Atlantic salmon

British Journal of Nutrition, 2019
Academic article

Effect of feed, temperature and stress on pigmentation in salmon

2019
Nofima’s reports

New omega-3 sources in diets of Atlantic salmon

2019
Nofima’s reports

Importance of nutrition for skin, intestine and gill health in Atlantic salmon

2019
Nofima’s reports

Alteration of mRNA abundance, oxidation products and antioxidant enzyme activities during oocyte ageing in common carp Cyprinus carpio

PLOS ONE, 2019
Academic article

Dietary impacts of sulphuric acid extracted fish bone compounds on astaxanthin utilization and muscle quality in Atlantic salmon (Salmo salar)

Aquaculture, 2018
Academic article

Effects of tetradecylthioacetic acid (TTA) treatment on lipid metabolism in salmon hearts—in vitro and in vivo studies

Fish Physiology & Biochemistry, 2018
Academic article

Functional amino acids stimulate muscle development and improve fillet texture of Atlantic salmon

Aquaculture Nutrition, 2018
Academic article

The role of extracellular matrix components in pin bone attachments during storage-a comparison between farmed Atlantic salmon (Salmo salar) and cod (Gadus morhua L.).

Fish Physiology & Biochemistry, 2017
Academic article

Low levels of very-long-chain n-3 PUFA in Atlantic salmon (Salmo salar) diet reduce fish robustness under challenging conditions in sea cages

Journal of Nutritional Science (JNS), 2017
Academic article

EPA, DHA, and Lipoic Acid Differentially Modulate the n-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes

Lipids, 2017
Academic article

Requirements of n-3 very long-chain PUFA in Atlantic salmon (Salmo salar L): effects of different dietary levels of EPA and DHA on fish performance and tissue composition and integrity

British Journal of Nutrition, 2017
Academic article

Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes

PLOS ONE, 2016
Academic article

The role of extracellular matrix components in pin bone attachments during storage—a comparison between farmed Atlantic salmon (Salmo salar) and cod (Gadus morhua L.)

Fish Physiology & Biochemistry, 2016
Academic article

Vil ketolinsyre (22:1n-11) fra lodde-, sild- og tobisolje føre til bedret utnyttelse av omega-3 fettsyrer?

2016
Nofima’s reports

Effekter av endret fettsyresammensetning i fôr til laks relatert til fiskens helse, velferd og robusthet (Fett for fiskehelse): Oppdatering 2016

2016
Nofima’s reports

Langtidseffekter av lave omega-3 nivåer i fôr på laksens helse

2016
Nofima’s reports

Metabolism, health and fillet nutritional quality in Atlantic salmon (Salmo salar) fed diets containing n-3-rich microalgae

Journal of Nutritional Science (JNS), 2015
Academic article

Kan nivå av EPA og DHA i fôr i tidlige livsfaser påvirke laksens helse og sammensetning i seinere livsfaser? FHF-prosjekt 900770 – Delrapport 1

2015
Nofima’s reports

Betydning av genetisk bakgrunn og ulike nivå av omega-3-fettsyrer i fôr i tidlig livsfaser for fiskehelse, fettsyresammensetning og muskelkvalitet ved slaktestørrelse FHF-prosjekt 900770 – delrapport 2

2015
Nofima’s reports

Kan forlenget opphold i ferskvann, før overføring til saltvann, påvirke laksens kapasitet til å omdanne 18:3 n-3 til EPA og DHA? FHF-prosjekt 900770 – delrapport 3

2015
Nofima’s reports

N-3 fatty acid intake altered fat content and fatty acid distribution in chicken breast muscle, but did not influence mRNA expression of lipid-related enzymes

Lipids in Health and Disease, 2014
Academic article

Helseeffekter i lakseceller eksponert for fiskebeinhydrolysater fra torsk, sild og kolmule

2014
Nofima’s reports

Feste av pinnebein i torsk og laks – bindevevets rolle og prosesser involvert i nedbrytning av dette. Sluttrapport

2014
Nofima’s reports

Fett for fiskehelse. Utredning: Effekter av endret fettsyre-sammensetning i fôr til laks relatert til fiskens helse, velferd og robusthet

2013
Nofima’s reports

Laksens helse, velferd og robusthet påvirkes av fettsyresammensetning i fôr

Norsk Fiskeoppdrett, 2013
Article in business/trade/industry journal

Kombinasjon av høye nivåer av vegetabilske fôroljer og lav sjøtemperatur; Sett i sammenheng med vekst og dødelighet hos regnbueørret i Nord

2013
Nofima’s reports

Lagringsstabilitet av et utvalg marine oljer. Effekt av oljekvalitet på cellulære responser – Fase 2

2013
Nofima’s reports

Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-14C] 18:3n-3 and [1-14C] 18:2n-6 in rainbow trout hepatocytes

Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology, 2013
Academic article

Kunnskap- og metodeutvikling for å styrke laksens robusthet og helse

2012
Nofima’s reports

High dietary EPA does not inhibit Delta 5 and Delta 6 desaturases in Atlantic salmon (Salmo salar L.) fed rapeseed oil diets

Aquaculture, 2012
Academic article

Gene Expression Profiling of Soft and Firm Atlantic Salmon Fillet

PLOS ONE, 2012
Academic article

In vivo and in vitro insulin and fasting control of the transmembrane fatty acid transport proteins in Atlantic salmon (Salmo salar)

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2011
Academic article

Influence of Dietary Sesamin, a Bioactive Compound on Fatty Acids and Expression of Some Lipid Regulating Genes in Baltic Atlantic Salmon (Salmo salar L.) Juveniles

Physiological Research, 2011
Academic article

High n-3 HUFA levels in the diet of Atlantic salmon affect muscle and mitochondrial membrane lipids and their susceptibility to oxidative stress

Aquaculture Nutrition, 2011
Academic article

Atlantic salmon (Salmo salar L.) flesh quality – role of lysosomal cathepsins B and L in muscle degradation

2010
Academic chapter/article/Conference paper

Atlantic salmon (Salmo salar) muscle precursor cells differentiate into osteoblasts in vitro: Polyunsaturated fatty acids and hyperthermia influence gene expression and differentiation

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2010
Academic article

Identification of a novel allele of peroxisome proliferator-activated receptor gamma (PPARG) and its association with resistance to Aeromonas salmonicida in Atlantic salmon (Salmo salar)

Fish and Shellfish Immunology, 2010
Academic article

Muscle structure responses and lysosomal cathepsins B and L in farmed Atlantic salmon (Salmo salar L.) pre- and post-rigor fillets exposed to short and long-term crowding stress

Food Chemistry, 2010
Academic article

Atlantic salmon (Salmo salar) muscle structure integrity and lysosomal cathepsins B and L influenced by dietary n-6 and n-3 fatty acids

Food Chemistry, 2009
Academic article

Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression

Lipids, 2008
Academic article

Molecular cloning of the Atlantic salmon activin receptor IIB cDNA – Localization of the receptor and myostatin in vivo and in vitro in muscle cells

Gene, 2007
Academic article

Myostatin (MSTN) gene duplications in Atlantic salmon (Salmo salar): Evidence for different selective pressure on teleost MSTN-1 and -2

Gene, 2007
Academic article

Molecular cloning of the Atlantic salmon activin receptor IIB cDNA – Localization of the receptor and myostatin in vivo and in vitro in muscle cells

Comparative Biochemistry and Physiology - Part D:Genomics and Proteomics, 2007
Academic article

Molecular characterization of a PDZ–LIM protein in Atlantic salmon (Salmo salar): a fish ortholog of the α-actinin-associated LIM-protein (ALP)

Journal of Muscle Research and Cell Motility, 2004
Academic article

Molecular characterization of a PDZ-LIM protein in Atlantic salmon (Salmo salar): a fish ortholog of the alpha-actinin-associated LIM-protein (ALP)

Journal of Muscle Research and Cell Motility, 2004
Academic article

Beta-oxidation, esterification, and secretion of radiolabeled fatty acids in cultivated Atlantic salmon skeletal muscle cells

Lipids, 2004
Academic article

The two myostatin genes of Atlantic salmon (Salmo salar) are expressed in a variety of tissues

European Journal of Biochemistry (EJB), 2001
Academic article