Published 2021

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Publication details

Journal : PLOS ONE , vol. 16 , p. 1–14 , 2021

International Standard Numbers :
Electronic : 1932-6203

Publication type : Academic article

Contributors : Lima, Rita de Cássia Lemos; Böcker, Ulrike; Allwood, J. William; Afseth, Nils Kristian; Wubshet, Sileshi Gizachew

Issue : 2

Research areas

Quality and measurement methods

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Summary

Article Authors Metrics Comments Media Coverage Abstract 1. Introduction 2. Materials and methods 3. Results and discussion 4. Conclusion Supporting information References Reader Comments (0) Figures Abstract In this work, a new magnetic ligand fishing probe for discovery of DPP-IV inhibitory ligands was developed and it was tested as a proof of concept on the fruit extract of Vaccinium vitis-idaea (lingonberry). The ligands were shown to have appreciable dipeptidyl peptidase IV (DPP-IV) inhibitory activity (IC50: 31.8 μg mL-1).) Inhibition of DPP-IV is a well-known therapeutic approach for management of type 2 diabetes (T2D). DPP-IV was successfully immobilized onto magnetic beads and was shown to retain its catalytic activity and selectivity over a model mixture. A total of four ligands were successfully fished out and identified as cyanidin-3-galactoside (2), cyanidin-3-arabinoside (3), proanthocynidin A (4), and 10-carboxyl-pyranopeonidin 3-O-(6″-O-p-coumaroyl)-glucoside (5) using HPLC/HRMS.

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