Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics
Publication details
Journal : Cell and Tissue Research , vol. 394 , p. 1–12 , 2023
International Standard Numbers
:
Printed
:
0302-766X
Electronic
:
1432-0878
Publication type : Academic article
Issue : 3
Links
:
DOI
:
doi.org/10.1007/s00441-023-038...
ARKIV
:
hdl.handle.net/11250/3110068
Research areas
Farmed fish
Breeding and genetics
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Kjetil Aune
Chief Librarian
kjetil.aune@nofima.no
Summary
Spatial transcriptomics is a technique that provides insight into gene expression profiles in tissue sections while retaining structural information. We have employed this method to study the pathological conditions related to red and melanized focal changes in farmed Atlantic salmon (Salmo salar). Our findings support a model where similar molecular mechanisms are involved in both red and melanized filet discolorations and genes associated with several relevant pathways show distinct expression patterns in both sample types. Interestingly, there appears to be significant cellular heterogeneity in the foci investigated when looking at gene expression patterns. Some of the genes that show differential spatial expression are involved in cellular processes such as hypoxia and immune responses, providing new insight into the nature of muscle melanization in Atlantic salmon.
