Published 2018

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Publication details

Journal : Nutrition & Metabolism , vol. 15 , p. 1–11 , 2018

Publisher : BioMed Central (BMC)

International Standard Numbers :
Printed : 1743-7075
Electronic : 1743-7075

Publication type : Academic article

Contributors : Walquist, Mari; Stormo, Svein Kristian; Østerud, Bjarne; Elvevoll, Edel Oddny; Eilertsen, Karl-Erik

Issue : 35

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Kjetil Aune
Chief Librarian


Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake of CLO in human intervention studies. Extracts from CWO deprived of fatty acids have also been shown to display antioxidative and anti-inflammatory effects in vitro. The aim of this study was to investigate whether intake of a high-fat Western-type diet (WD) supplemented with CWO would prevent the development of atherosclerotic lesions in apolipoprotein E-deficient (ApoE−/−) mice.