Published 2000

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Publication details

Journal : International journal of food microbiology , vol. 62 , p. 57–63 , 2000

Publisher : Elsevier

International Standard Numbers :
Printed : 0168-1605
Electronic : 1879-3460

Publication type : Academic article

Contributors : Aase, Berit Margrethe; Sundheim, Gunhild; Langsrud, Solveig; Rørvik, Liv Marit

Issue : 1-2

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Kjetil Aune
Chief Librarian


In a study of 200 Listeria monocytogenes isolates, 10% were determined to be resistant to benzalkonium chloride (BC). Serial subcultivation of initially BC sensitive (BCS) and BC resistant (BCR) isolates in sublethal concentrations of BC resulted in enhanced and approximately equal resistance of all strains to the compound. Fifty per cent of the BCR isolates showed resistance to ethidium bromide (EB) as well. A proton motive force (pmf)-dependent efflux of EB was demonstrated in BCR isolates, and in originally sensitive strains adapted to grow in BC. This efflux was not found in BCS strains. The result indicate that BC can induce a broad resistance mechanism based on a pmf-driven efflux pump. There was no indication that this type of resistance was related to resistance to antibiotics. (C) 2000 Elsevier Science B.V. All rights reserved.