Published 2010

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Publication details

Journal : The ISME Journal , p. 1–13–13 , 2010

Publisher : Nature Publishing Group

International Standard Numbers :
Printed : 1751-7362
Electronic : 1751-7370

Publication type : Academic article

Contributors : Sekelja, Monika; Berget, Ingunn; Næs, Tormod; Rudi, Knut

Issue : 26.aug

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The potential presence of widespread and stable bacterial core phylogroups in the human colon has promoted considerable attention. Despite major efforts, no such phylogroups have yet been identified. Therefore, using a novel phylogroup- and tree-independent approach, we present a reanalysis of 1?114?722 V2 region and 71?550 near full-length 16S rRNA sequences from a total of 210 human beings, with widespread geographic origin, ethnic background and diet, in addition to a wide range of other mammals. We found two highly prevalent core phylogroups (cores 1 and 2), belonging to the clostridial family Lachnospiraceae. These core phylogroups showed a log-normal distribution among human individuals, while non-core phylogroups showed more skewed distributions towards individuals with low levels compared with the log-normal distribution. Molecular clock analyses suggest that core 2 co-evolved with the radiation of vertebrates, while core 1 co-evolved with the mammals. Taken together, the stability, prevalence and potential functionality support the fact that the identified core phylogroups are pivotal in maintaining gut homeostasis and health.