Published 2009

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Publication details

Journal : Chemometrics and Intelligent Laboratory Systems , vol. 98 , p. 10–23–14 , 2009

Publisher : Elsevier

International Standard Numbers :
Printed : 0169-7439
Electronic : 1873-3239

Publication type : Academic article

Contributors : Gjerstad, Øystein; Aakra, Ågot; Indahl, Ulf

Issue : 1

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Based on a recently developed spot segmentation method, we here present a new approach to modelling of individual spots in digital images, e.g. images of DNA microarrays. From the model parameter estimates and residuals we have developed an expedient approach to automatic quality assessment and identification of corrupted spots. The suggested approach to quality control is shown to give a statistically significant decrease of the variance in gene expression log-ratio estimates for three different DNA microarray datasets. (C) 2009 Published by Elsevier B.V.