Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms

Published 2007

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Publication details

Journal : BMC Systems Biology , vol. 1 , p. 12–1 , 2007

Publisher : BioMed Central (BMC)

International Standard Numbers :
Printed : 1752-0509
Electronic : 1752-0509

Publication type : Academic article

Contributors : Gjuvsland, Arne Bjørke; Hayes, Ben J.; Meuwissen, Theo; Plahte, Erik; Omholt, Stig W.

Issue : art. 32

Links :
OMTALE : http://www.biomedcentral.com/1...

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Summary

Conclusion: Our findings indicate that genetic variation affecting the form of cis-regulatory input functions may reshape the genotype-phenotype map by changing the relative importance of cis and trans variation. Our approach combining nonlinear dynamic models with statistical genetics opens up for a systematic investigation of how functional genetic variation is translated into phenotypic variation under various systemic conditions.