Published 2000

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Publication details

Journal : Journal of Fish Diseases , vol. 23 , p. 115–127–13 , 2000

Publisher : Blackwell Publishing

International Standard Numbers :
Printed : 0140-7775
Electronic : 1365-2761

Publication type : Academic article

Contributors : Bakke McKellep, Anne Marie; Press, Charles McLean; Bæverfjord, Grete; Krogdahl, Åshild; Landsverk, Thor

Issue : 2

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Kjetil Aune
Chief Librarian


Extracted soybean meal (SBM) in the diet for Atlantic salmon causes an inflammatory response in the distal intestine. The morphological changes of the epithelial cells and a characterization of the inflammatory cell infiltrate of the distal intestinal mucosa were studied using a panel of enzyme and immunohistochemical markers. The salmon used in the study were fed either a fishmeal-based diet or a diet in which 30% of the fishmeal protein was replaced with SBM protein. SBM-fed salmon had markedly reduced enzyme activities in the distal intestinal epithelial cells, both in the brush border and in intracellular structures. There appeared to be an increased presence of cells of monocytic lineage, including macrophages, as well as neutrophilic granulocytes and immunoglobulin M (IgM) in the lamina propria of SBM-fed fish. The mid intestine showed little response to the diet. The results suggest that toxic/antigenic component(s) of SBM affect the differentiation of the distal intestinal epithelial cells and may help explain the reduced nutrient digestibilities previously reported in salmonids fed extracted SBM.