Published 2019

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Publication details

Journal : European Journal of Nutrition , p. 1–17 , 2019

International Standard Numbers :
Printed : 1436-6207
Electronic : 1436-6215

Publication type : Academic article

Contributors : Hovland, Ida Heir; Leikanger, Ingrid Sande; Stokkeland, Oddbjørg; Waage, Kaia Hevrøy; Mjøs, Svein Are; Brokstad, Karl Albert; McCann, Adrian; Ueland, Per Magne; Slizyte, Rasa; Carvajal, Ana Karina; Mellgren, Gunnar; Remman, Tore; Høgøy, Ingmar Johan; Gudbrandsen, Oddrun Anita

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Purpose To examine whether supplementation with low doses of fish or milk proteins would affect glucose regulation and circulating lipid concentrations in overweight healthy adults. Methods Ninety-three overweight adults were assigned to receive 2.5 g protein/day from herring (HER), salmon (SAL), cod (COD) or milk (CAS, a casein–whey mixture as positive control) as tablets for 8 weeks. Results Seventy-seven participants were included in the analyses. HER and SAL did not affect glucose and insulin concentrations. COD significantly reduced within-group changes in 90 and 120 min postprandial glucose concentrations but changes were not different from HER and SAL groups. CAS supplementation significantly reduced the area under the curve for glucose concentrations (− 7%), especially when compared to SAL group, and reduced postprandial insulin c-peptide concentration (− 23%). Reductions in acetoacetate (− 24%) and β-hydroxybutyrate (− 29%) serum concentrations in HER group were more prominent compared to SAL and COD groups, with no differences between fish protein groups for α-hydroxybutyrate. Serum concentrations of α-hydroxybutyrate (− 23%), acetoacetate (− 39%) and β-hydroxybutyrate (− 40%) were significantly reduced within CAS group, and the decreases were significantly more pronounced when compared to SAL group. Serum lipid concentrations were not altered in any of the intervention groups. Conclusion Findings indicate that 2.5 g/day of proteins from fish or milk may be sufficient to improve glucose regulation in overweight adults. The effects were most pronounced after supplementation with proteins from cod, herring and milk, whereas salmon protein did not affect any of the measurements related to glucose regulation. Clinical trail registration This trial was registered at as NCT01641055.